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Initial targeted areas of application for the Company's drug delivery technology include pain management, inflammation, anti-adhesion and protein delivery applications. Our Biochronomer(TM) systems were specifically designed retin a micro prescription for the release of drugs into various sites such as under the skin, in muscle, or in the peritoneal cavity, and we believe that they offer potential for use in a broad array of pharmaceutical products. The company's primary focus is the development and commercialization of its bioerodible injectable and implantable systems under the trade name Biochronomer(TM). Dermatologists who conducted the pivotal clinical studies believe this may be retin a micro prescription why most RETIN-A MICRO patients experience little or no irritation. For further information about RETIN-A retin a micro prescription micro, visit www. Retinamicro.
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Other risks and uncertainties associated with the company's business and prospects are identified in the company's filings with the Securities and Exchange Commission. Patients may see therapeutic results in two Retin a micro prescription to seven weeks of treatment with RETIN-A MICRO. Johnson & Johnson Canada will market retin a micro prescription the product in Canada under the same U.

Other risks and uncertainties associated with the company's business and prospects are identified in the company's filings with the Securities and Exchange Commission. Food and Drug Administration (FDA) for a second formulation of Retin-A Micro(R), a leading topical acne treatment. We are very pleased with the level of royalties generated by Carac following its recent introduction in March 2001. The retin a micro prescription most common adverse reactions to RETIN-A MICRO were limited to mild or moderate irritation of the skin. In clinical studies, the RETIN-A MICRO irritation profile was found to be similar to a retin a micro prescription mild, local irritant. Six percent of patients discontinued due to irritation. Statistically significant reductions were reported by the investigator in the appearance of facial shine (oiliness) at three and six hours after application of RETIN-A MICRO as compared to baseline.

And we anticipate that it will enjoy similar success in Canada. Study participants' skin was evaluated by the study investigator and by the subjects at baseline and at three and six hours after application of the two test products.
Note: See enclosed package inserts for full U. For further information visit the Company's Web site at www. Appharma everyone, will regulate retin a micro prescription. Retin a micro prescription as if upon commercialization, anticipated in the third quarter of 2001, ap pharma will begin to receive royalties on product sales. (Nasdaq:APPA), a specialty pharmaceutical company, today announced that a New Drug Application (NDA) has been filed with the U. The Company does not undertake to revise these forward-looking statements to reflect events or circumstances occurring in the future.

Business Editors & Health/Medical Writers REDWOOD CITY, Calif. --(BW HealthWire)--May 3, 2001 Advanced Polymer Systems Inc. Forward-looking Statements Except for historical information, this news release contains certain forward-looking statements that involve risks and uncertainties, including among others, uncertainty associated with timely development, approval, launch and acceptance of new products, establishment of new corporate alliances and progress in research and development programs. (Nasdaq:APPA), a specialty pharmaceutical company, today announced that Canadian drug regulatory authorities have granted marketing clearance for Retin-A Micro(R) (tretinoin gel) microsphere, 0.

1% for the treatment of acne. MICROSPONGE(R) is a registered trademark of Advanced Polymer Systems, Inc polluted retin a micro prescription because. Retin a micro prescription than the company's primary focus is the development and commercialization of its bioerodible injectable and implantable systems under the trade name biochronomer(tm). Sales of Retin-A Micro in Canada will add to our existing royalty streams and we look forward to benefiting from product line extensions and continued geographic expansion by Johnson & Johnson, commented Mike O'Connell, AP Pharma's president and chief executive officer.
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The company's product development programs are funded by royalties from topical products currently marketed by pharmaceutical partners and proceeds from the divestiture of its cosmeceutical product lines.
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About Advanced Polymer Systems Advanced Polymer Systems is a specialty pharmaceutical company focused on the development of ethical (prescription) pharmaceuticals utilizing its proprietary polymer-based drug delivery systems.
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